Overactive bladder mediated by accelerated Ca influx mode of Na /Ca exchanger in smooth muscle
نویسندگان
چکیده
Hisao Yamamura,* William C. Cole,* Satomi Kita, Shingo Hotta, Hidemichi Murata, Yoshiaki Suzuki, Susumu Ohya, Takahiro Iwamoto, and Yuji Imaizumi Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan; The Smooth Muscle Research Group, Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Canada; Department of Pharmacology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; and Department of Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan
منابع مشابه
Overactive bladder mediated by accelerated Ca2+ influx mode of Na+/Ca2+ exchanger in smooth muscle.
The Na(+)/Ca(2+) exchanger (NCX) is thought to be a key molecule in the regulation of cytosolic Ca(2+) dynamics. The relative importance of the two Ca(2+) transport modes of NCX activity leading to Ca(2+) efflux (forward) and influx (reverse) in smooth muscle, however, remains unclear. Unexpectedly, spontaneous contractions of urinary bladder smooth muscle (UBSM) were enhanced in transgenic mic...
متن کاملNa(+)/Ca(2+) exchange and its role in intracellular Ca(2+) regulation in guinea pig detrusor smooth muscle.
The role of Na(+)/Ca(2+) exchange in regulating intracellular Ca(2+) concentration ([Ca(2+)](i)) in isolated smooth muscle cells from the guinea pig urinary bladder was investigated. Incremental reduction of extracellular Na(+) concentration resulted in a graded rise of [Ca(2+)](i); 50-100 microM strophanthidin also increased [Ca(2+)](i). A small outward current accompanied the rise of [Ca(2+)]...
متن کاملVascular Na /Ca exchanger: implications for the pathogenesis and therapy of salt-dependent hypertension
Iwamoto, Takahiro. Vascular Na /Ca exchanger: implications for the pathogenesis and therapy of salt-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 290: R536–R545, 2006; doi:10.1152/ajpregu.00592.2005.—The Na /Ca exchanger is an ion transporter that exchanges Na and Ca in either Ca efflux or Ca influx mode, depending on membrane potential and transmembrane ion gradients. In arter...
متن کاملInvited Review CALL FOR PAPERS Molecular Mechanisms Linking Salt to Hypertension Vascular Na /Ca exchanger: implications for the pathogenesis and therapy of salt-dependent hypertension
Iwamoto, Takahiro. Vascular Na /Ca exchanger: implications for the pathogenesis and therapy of salt-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 290: R536–R545, 2006; doi:10.1152/ajpregu.00592.2005.—The Na /Ca exchanger is an ion transporter that exchanges Na and Ca in either Ca efflux or Ca influx mode, depending on membrane potential and transmembrane ion gradients. In arter...
متن کاملRole of Na /Ca exchange in regulating cytosolic Ca in cultured human pulmonary artery smooth muscle cells
Zhang, Shen, Jason X.-J. Yuan, Kim E. Barrett, and Hui Dong. Role of Na /Ca exchange in regulating cytosolic Ca in cultured human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol 288: C245–C252, 2005. First published September 29, 2004; doi:10.1152/ajpcell.00411.2004.—A rise in cytosolic Ca concentration ([Ca ]cyt) in pulmonary artery smooth muscle cells (PASMC) is an important s...
متن کامل